WebSep 18, 2024 · NCBI Bookshelf WebOtotoxicity was more severe with higher cumulative doses and higher individual doses, and was most marked in those patients receiving bolus injections. Loss of perception of higher frequencies was most common. Symptoms of ototoxicity occurred in 23 patients and included deafness, tinnitus, otalgia, and recruitment.
Cisplatin RxWiki
WebSerum platinum levels and cisplatin induced ototoxicity among pediatric germ cell tumor survivors. Lacy Pehlke. MPH, Epidemiology. Co-Authors: Jen Poynter, Michelle Roesler & Jeannette Sample ... We will measure the association between blood serum platinum levels and ototoxicity, while adjusting for age at treatment, time since diagnosis, tumor ... WebJul 3, 2024 · However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated. It is generally accepted … fc薄膜
Ototoxicity in patients receiving cisplatin: importance of
WebMechanistically, cisplatin ototoxicity is associated with the absence of glutathione (GSH) and the inhibition of glutathione peroxidase (GSH.Px) and glutathione reductase activities because cisplatin can covalently bind to the sulfhydryl groups of anti-oxidant enzymes, causing enzyme inactivation. 2 Increased lipid peroxidation in the cochlea ... WebJun 21, 2024 · This trial compared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects without jeopardizing overall and event-free survival. Methods: WebAssociation of Sodium Thiosulfate With Risk of Ototoxic Effects From Platinum-Based Chemotherapy: A Systematic Review and Meta-analysis Oncology JAMA Network Open JAMA Network This systematic review and meta-analysis investigates 4 studies for the association of sodium thiosulfate with reduced risk of ototoxic effects among patients t fc 薬剤