Dexrazoxane used with doxorubicin

Author: vmxg

August undefined, 2024

WebOct 22, 2015 · Dosing is a 10:1 ratio of dexrazoxane to doxorubicin; doxorubicin is typically given at 75 mg/m2, so dexrazoxane dosing would be 750 mg/m2. In the event of a national shortage of dexrazoxane, 72-hour infusional doxorubicin can be used instead of dexrazoxane and bolus doxorubicin.. WebCOMMON BRAND NAME (S): Zinecard. USES: Dexrazoxane is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer chemotherapy medications. Heart damage …

Dexrazoxane - StatPearls - NCBI Bookshelf

WebThe recommended dexrazoxane : doxorubicin (or epirubicin) dosage ratio is 10 : 1 (e.g., if 40 mg/m 2 of doxorubicin is used, 400 mg/m 2 of dexrazoxane should be administered). A reconstituted dexrazoxane solution should be administered intravenously by slow push starting 15 to 30 minutes before intravenous administration of anthracycline. WebDexrazoxane should only be used in adult patients with advanced or metastatic breast cancer. The benefits of dexrazoxane do not outweigh its risks in children and adolescents. Dexrazoxane should only be used in adult patients who have already received a minimum cumulative anthracycline dose of 300 mg/m 2 of doxorubicin, or 540 mg/m 2 of epirubicin. greenwood public library sc

Dexrazoxane: Package Insert - Drugs.com

Dexrazoxane injection is available as 2 different products that are used to treat or prevent certain side effects that may be caused by certain chemotherapy medications. Dexrazoxane injection (Zinecard) is used to prevent or decrease heart damage caused by doxorubicin in women who are taking the medication … See more Some people who took a medication that is very similar to dexrazoxane injection developed new forms of cancer. There is not enough information to tell if receiving dexrazoxane … See more It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as … See more Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to dexrazoxane injection. Ask your doctor or pharmacist any questions you have about … See more WebZinecard ® (dexrazoxane for injection) DESCRIPTION ZINECARD ® (dexrazoxane for injection) is a sterile, pyrogen-free lyophilizate intended for intravenous administration. It … WebDoxorubicin is used in combination with other medications to treat certain types of bladder, breast, lung, stomach, and ovarian cancer; Hodgkin's lymphoma (Hodgkin's disease) and … greenwood public school sector 9

Zinecard - Chemotherapy Drugs - Chemocare

WebUse of dexrazoxane as a cardioprotectant in patients receiving doxorubicin or epirubicin chemotherapy for the treatment of cancer. Cancer Prev Control 1999 ;3: 145 - 159 Medline WebDexrazoxane is the generic name for the trade name drug Zinecard. In some cases, health care professionals may use the trade name Zinecard when referring to the generic drug … greenwood public school gwaliorWebHowever, cardiotoxicity is one of the life-threatening side effects of doxorubicin-based therapy. Dexrazoxane (Zinecard, also known as … foam roller how to choose

"WebThere is some evidence that the use of dexrazoxane concurrently with the initiation of fluorouracil, doxorubicin, and cyclophosphamide (FAC) therapy interferes with the antitumor efficacy of the regimen, and this use is not recommended. ... The recommended dosage ratio of ZINECARD:doxorubicin is 10:1 (e.g., 500 mg/m2 ZINECARD:50 mg/m2 ... " - Dexrazoxane used with doxorubicin

Dexrazoxane used with doxorubicin

DEXRAZOXANE (AuroMedics Pharma LLC): FDA Package Insert

WebFor doxorubicin, use of dexrazoxane is recommended after the cumulative dose reaches 300 mg/m2 (i.e., 55% of the recommended maximum). A similar formula could be used for epirubicin, that is, institution of dexrazoxane when the cumulative dose of epirubicin reaches 550 mg/m2, as the recommended maximum cumulative dose in Canada is 1000 … Webdexrazoxane for cardiomyopathy, reduce the Totect dosage proportionately (maintaining the 10:1 ratio) in patients with hepatic impairment, since a doxorubicin dose reduction is recommended in the presence of hyperbilirubinemia [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)]. 2.4 Preparation

Did you know?

WebApr 11, 2024 · Prolonged local delivery of doxorubicin to cancer cells using lipid liquid crystalline system. Author links open overlay panel Malihe Karimi a 1 ... is used to dissolve the amphiphilic moieties and tween 80 is usually used to produce a homogenized vehicle solution and to modify the release pattern of the loaded drug. NMP is an FDA approved … WebAug 16, 2024 · Dexrazoxane is a medication used in the management and treatment of anthracycline-induced cardiotoxicity and extravasation injuries. It is in the class of medications known as cardioprotectants. ... The …

WebDexrazoxane hydrochloride is approved to treat severe side effects caused by certain types of chemotherapy. It is used to treat the following: Cardiac (heart) side effects caused by … WebDexrazoxane (Cardioxane, Zinecard, a cyclic derivative of edetic acid, is a site-specific cardioprotective agent that effectively protects against anthracycline-induced cardiac …

WebApr 10, 2024 · The initial cumul ative doses of doxorubicin used in oste-osarcoma were high, exceeding 450 mg/m. 2. These doses. ... Dexrazoxane has been used in comb ination of doxorubi-cin to prevent heart ... WebNov 5, 2024 · When dexrazoxane injection is used to prevent heart damage caused by doxorubicin, it is given just before each dose of doxorubicin, by intravenous (IV, into a vein) infusion. When used to prevent tissue damage after extravasation, it is given once a day for 3 days, beginning no more than 6 hours after the leakage.

WebNov 5, 2024 · When dexrazoxane injection is used to prevent heart damage caused by doxorubicin, it is given just before each dose of doxorubicin, by intravenous (IV, into a …

Webdexrazoxane for cardiomyopathy, reduce the Totect dosage proportionately (maintaining the 10:1 ratio) in patients with hepatic impairment, since a doxorubicin dose reduction is … foam roller hip painWebAnthracyclines such as doxorubicin are widely used chemotherapy drugs in both adults and children for hematologic malignancies, soft-tissue sarcomas, and solid tumors of the breast, lung, stomach, bladder, and ovaries. ... At present, the iron chelator, dexrazoxane, is the only drug approved by the US FDA to counteract anthracycline cardiotoxicity. foam roller hip mobilityWebAvoid concurrent use of doxorubicin HCl with inhibitors and inducers of CYP3A4, CYP2D6, and/or P-gp (7.1). ... In adults, consider administration of dexrazoxane [see Warnings and Precautions (5.3)]. Incompatibility with Other Drugs . Do not admix doxorubicin HCl with other drugs. If doxorubicin HCl is mixed with heparin or foam roller hip stretchesWebJan 12, 2024 · The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an … greenwood public school user loginWebFeb 17, 2024 · Dosing: Pediatric. Prevention of anthracycline cardiomyopathy associated with acute lymphoblastic leukemia (ALL): Limited data available: Infants, Children, and Adolescents: IV: A 10:1 dose ratio of dexrazoxane:doxorubicin (example: 300 mg/m 2 dexrazoxane: 30 mg/m 2 doxorubicin) (Lipshultz 2010; Moghrabi 2007; Silverman 2010). foam roller instructions pdfWebDoxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. It is often used together with other chemotherapy agents. Doxorubicin is given by injection into a vein.. Common side … greenwood public school sector 9 gurugramWebDexrazoxane is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer chemotherapy medications. Heart damage limits the length of time you can be ... greenwood publisher